翻訳と辞書 Words near each other ・ Autopass ・ Autopass Card ・ Autopatch ・ AutoPatcher ・ Autoped ・ Autopen ・ Autophagia ・ Autophagin ・ Autophagocytosis associated protein Atg3 ・ Autophagomyces ・ Autophagosome ・ Autophagy ・ Autophagy (disambiguation) ・ Autophagy (journal) ・ Autophagy database ・ Autophagy-related protein 101 ・ Autophagy-related protein 13 ・ Autopharmacology ・ Autophila ・ Autophila anaphanes ・ Autophila cerealis ・ Autophila einsleri ・ Autophila libanotica ・ Autophila ligaminosa ・ Autophila limbata ・ Autophila pauli ・ Autophobia ・ Autophone ・ Autophony ・ Autophosphorylation Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Autophagy-related protein 101 ： ウィキペディア英語版 Autophagy-related protein 101 Autophagy-related protein 101 also known as ATG101 is a protein that in humans is encoded by the ''C12orf44'' gene (chromosome 12 open reading frame 44).〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60673 )〕 Autophagy is the process of forming a vacuole around proteins and nucleic acids that are to be broken down in lysosomes. The transcribed mRNA sequence of C12orf44 is 1287 base pairs, and following translation the sequence is 218 amino acids in length. The ATG101 protein is localized in the cytoplasm, but can possibly also be found bound to a structure known as a phagophore, involved in autophagy. The gene is highly conserved among mammals, as well as showing conservation among most eukaryotes. It is thought to directly interact with ATG13 in the ULK1 complex, which may be important for activating phagophores. == Function == ATG101 is a newly found important autophagy related protein, among many other proteins responsible for autophagy, a process well conserved among most eukaryotic organisms. However, ATG101 is not homologous to any of the other ATG proteins. ATG101 interacts with essential autophagy protein ATG13 in mammals, which is a ULK1 interacting protein. ULK1 (unc-51-like kinase 1) is thought to be important to the activation of macroautophagy in mammals. ATG101 is suggested to protect ATG13 from proteasomal degradation, therefore stabilizing levels of ATG13 found in cells and regulating levels of macroautophagy. According to published papers, ATG101 is said to localize to the isolation membrane, also known as a phagophore. This attachment to the phagophore could possibly explain the palmitoylation site found on the third AA, which is a cysteine. Phagophores are responsible for recognizing and surrounding materials that are to be degraded in the lysosome, by forming a membrane that completely surrounds the materials to be degraded. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Autophagy-related protein 101」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.